What is the difference between single-stranded DNA and double-stranded DNA?
Genetics is the study of inheritance. The genetic makeup of an organism is transmitted via DNA replication. The DNA can either be single-stranded or double-stranded.
The core difference between single-stranded DNA and double-stranded DNA is that single-stranded DNA has a star shape while double-stranded DNA has a linear form.
What Is Single-Stranded DNA?
Single-stranded DNA is a star-shaped genetic makeup and it is less stable. It behaves as randomly coiled polymers and it tends to be present in some viruses.
What Is Double-Stranded DNA?
Double-stranded DNA is a linear form of genetic makeup and it is quite stable. It behaves like a rigid rod-like structure and it is present in all organisms.
Comparison Chart: Single-Stranded DNA vs. Double-Stranded DNA
|Basic Terms||Single-Stranded DNA||Double-Stranded DNA|
|Appearance||Have a stellate or star shape||Have a linear or filamentous shape|
|Composition Relationship||No relationship||Thymine is equal to adenine. Guanine is equal to cytosine|
|The ratio of A: T||0.77||1|
|The ratio of G:C||1.3||1|
|Stability||less stable||More stable|
|Resistance to formaldehyde||Prone to action||Quite resistant|
|UV absorption||Increases from 20 to 900c||Increases from 0 to 800c|
|Morphology||Randomly coiled polymer||Rigid rod-like structure|
|Occurrence||Few viruses||All organism|
|Chargaff rule||Do not follow||Tend to follow|
|The ratio of purine and pyrimidine||Tend to vary||1|
Core Difference between Single-Stranded DNA and Double-Stranded DNA
- Single-stranded DNA occur in few viruses while double-stranded DNA occurs in all organism
- Double-stranded DNA follow chargaff rule while single-stranded DNA do not follow chargaff rule
- The ratio of purine and pyrimidine in single-stranded DNA tend to vary greatly while in double-stranded is one
- Thymine is equal to adenine in double-stranded DNA while there is no such relationship in single-stranded DNA
- Double-stranded DNA has linear or filamentous form while single-stranded has stellate or star shape form
- Single-stranded DNA have randomly coiled polymer while double-stranded DNA has a rigid rod-like structure
- The UV absorption of single-stranded DNA increases from 20 to 900c while that of double-stranded increases from 0 to 800c
- Double-stranded DNA is more stable while single-stranded DNA is less stable
- Double-stranded DNA is resistant to the action of formaldehyde while single-stranded is highly prone to the action of formaldehyde
- The ratio of guanine to cytosine in double-stranded DNA is one while in single-stranded DNA is 1.3
- The ratio of thymine to adenine in double-stranded DNA is one while in single-stranded is 0.77
Similarities between Single-Stranded DNA and Double-Stranded DNA
- Both deal with genetic material
- Both are polymers of nucleic acid
- Both contain purine and pyrimidine
- Both contain a nitrogenous base
- Both absorb UV light
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The core difference between single-stranded DNA and double-stranded DNA is that single-stranded DNA has a stellate or star shape and double-stranded has rigid rod-like structures. Both deal with the genetic makeup of an organism.